Development of an objective evaluation method of diagnosis and therapeutic effect in children with attention-deficit/hyperactivity disorder using resting state functional magnetic resonance imaging

2017 Fiscal Year Final Research Report

• Project/Area Number: 16K16621
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Childhood science (childhood environment science)
• Research Institution: University of Fukui
• Principal Investigator: MIZUNO Yoshifumi 福井大学, 学術研究院医学系部門(附属病院部), 特命助教 (50756814)
• Research Collaborator: JUNG Mingyoung 福井大学, 子どものこころの発達研究センター, 特命助教 ; FUJISAWA Takashi 福井大学, 子どものこころの発達研究センター, 講師 ; TAKIGUCHI Shinichiro 福井大学, 学術研究院医学系部門(附属病院部), 特命助教 ; SHIMADA Koji 福井大学, 子どものこころの発達研究センター, 特命助教 ; SAITO Daisuke 金沢大学, 子どものこころの発達研究センター, 特任准教授 ; KOSAKA Hirotaka 福井大学, 子どものこころの発達研究センター, 教授 ; TOMODA Akemi 福井大学, 子どものこころの発達研究センター, 教授
• Project Period (FY): 2016-04-01 – 2018-03-31
• Keywords: 注意欠如多動症（ADHD) / 安静時fMRI / COMT / 小脳 / メチルフェニデート

Outline of Final Research Achievements

The aim of the present study is to clarify the neural basis of attention-deficit/ hyperactivity disorder (ADHD). We examined whether the cortico-cerebellar executive function network is altered in children with ADHD and whether catechol-O-methyltransferase (COMT) polymorphism is associated with the altered network using resting-state functional MRI. Relative to TD controls, children with ADHD showed significantly lower functional connectivity of the right Crus I/II with the left dorsolateral prefrontal cortex. Additionally, the functional connectivity of children with ADHD was modulated by COMT polymorphism. These results suggest that COMT polymorphism effects on the cortico-cerebellar executive function network, which effects on executive function and ADHD symptoms. Further imaging genetics study may lead to the development of objective diagnostic and therapeutic effect evaluation system according to ADHD pathophysiology.

Free Research Field

小児発達学