Development of glycan-immobilized field effect transistor based biosensors toward the detection of mutated influenza viruses

2017 Fiscal Year Final Research Report

• Project/Area Number: 16K17498
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Nanobioscience
• Research Institution: Waseda University
• Principal Investigator: Hideshima Sho 早稲田大学, ナノ・ライフ創新研究機構, 次席研究員(研究院講師) (10580433)
• Project Period (FY): 2016-04-01 – 2018-03-31
• Keywords: 電界効果トランジスタバイオセンサ / インフルエンザウイルス / 糖鎖 / バイオセンシング / ナノバイオ界面

Outline of Final Research Achievements

In the project, a glycan-immobilized field effect transistor (FET) based biosensor toward the detection of mutated influenza viruses has been developed. The glycan-immobilized FET biosensors, which were modified with Siaα2,6’Gal and Siaα2,3’Gal, successfully detected human and avian influenza viral particles, respectively, suggesting that mutant influenza viruses, which has their recognition ability both to Siaα2,6’Gal and Siaα2,3’Gal, could be rapidly identified by the biosensors.

Free Research Field

ナノバイオサイエンス