Development of novel trifluoromethyl radical sources

2017 Fiscal Year Final Research Report

• Project/Area Number: 16K17869
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Organic chemistry
• Research Institution: Yamaguchi University
• Principal Investigator: Kawamoto Takuji 山口大学, 大学院創成科学研究科, 助教 (70756139)
• Research Collaborator: SASAKI Rio 山口大学, 大学院創成科学研究科, 大学院生 ; ORITANI Kyohei 山口大学, 大学院創成科学研究科, 大学院生 ; SHIMAYA Yudai 山口大学, 大学院創成科学研究科, 大学院生 ; MII Junya 山口大学, 大学院創成科学研究科, 大学院生 ; KAWABATA Atsushi 山口大学, 大学院創成科学研究科, 大学院生 ; KAMIMURA Akio 山口大学, 大学院創成科学研究科, 教授
• Project Period (FY): 2016-04-01 – 2018-03-31
• Keywords: トリフルオロメチル / ラジカル / トリエチルボラン / トリフルオロメタンスルホン酸無水物

Outline of Final Research Achievements

Trifluoromethylated compounds are the most important class of structural motifs, especially in the fields of pharmaceuticals, agrochemicals, and fine chemicals. α-Trifluoromethylated ketones are useful building blocks that can serve as versatile precursors to drug-like compounds. For the preparation of such α-trifluoromethylated ketones, several methods have been developed. All these methods require external trifluoromethyl sources, which often contain large activating groups. In this work, we have developed a novel method using trifluoromethanesulfonic anhydride as the activator for the ketone and as the trifluoromethyl source.

Free Research Field

有機合成化学