2017 Fiscal Year Final Research Report
Construction of Functional Interfaces based on Precision Polymer Synthesis: Novel Design of Blood-compatible Polymers
Project/Area Number |
16K17917
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Polymer chemistry
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Research Institution | Kyushu University |
Principal Investigator |
Oda Yukari 九州大学, 工学研究院, 助教 (20625595)
|
Project Period (FY) |
2016-04-01 – 2018-03-31
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Keywords | 高分子膜 / 精密合成 / 血液適合性 / 水 / 界面 / 表面濃縮 / ハイドロゲル |
Outline of Final Research Achievements |
Excellent bio-inert properties of polymers are strongly related to aggregation states and dynamics of chains at the water interface. In this study, we prepared a series of well-defined polymer thin films and examined relationship between their structure and physical properties at the water interface, and blood-compatibility. First, a branched polymer grafted with hydrophilic polymer chains was successfully prepared. Its hydrophilic part was preferentially segregated at the outermost surface of the blend films with a linear polymer and effectively prevented protein adsorption on their surfaces. Furthermore, the cross-linked thin films of water-soluble polymers were prepared. The obtained films were thickened in water. The moduli of the hydrogel films near the water interfaces were greatly sensitive to the cross-linking density of the polymers. Diffuse interfaces of the polymer chains at the water interface made it possible to prevent the platelet adhesion on the films.
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Free Research Field |
高分子化学
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