Adsorption behavior of drugs for preparation of nano DDS career using supercritical deposition method

2017 Fiscal Year Final Research Report

• Project/Area Number: 16K18273
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Properties in chemical engineering process/Transfer operation/Unit operation
• Research Institution: Hiroshima University (2017); Tohoku University (2016)
• Principal Investigator: Ushiki Ikuo 広島大学, 工学研究科, 助教 (30734850)
• Project Period (FY): 2016-04-01 – 2018-03-31
• Keywords: 薬剤 / ドラッグデリバリーシステム / 吸着 / 超臨界 / メソポーラスシリカ / 担持 / 含浸 / 二酸化炭素

Outline of Final Research Achievements

Adsorption behavior of drugs (ibuprofen and ketoprofen) onto MCM-41-type mesoporous silica using supercritical carbon dioxide was studied for preparation of nano DDS (drug delivery system) career. The experiments were carried out at temperatures from 313 to 343 K and at a pressure of 15.0 MPa. The loading amount of the drugs onto the mesoporous silica adsorbent increased with increasing temperature. This can be attributable to the solubility of the drug in supercritical carbon dioxide and competitive adsorption of carbon dioxide with the drug. Therefore, efficient design of the preparation process of the supercritical carbon dioxide method requires considerations of these effects for the drug loading onto the mesoporous material.

Free Research Field

超臨界流体工学，基礎物性，吸着分離