2017 Fiscal Year Final Research Report
Distribution of seeding activity in patients with sporadic CJD using RT-QUIC
| Project/Area Number |
16K18384
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Nerve anatomy/Neuropathology
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| Research Institution | University of Miyazaki (2017)
Nagasaki University (2016) |
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Principal Investigator |
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Keywords | プリオン / クロイツフェルト・ヤコブ病 / 試験管内異常型プリオン増幅法 / シード活性 / 非神経系組織 |
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| Outline of Final Research Achievements |
Human prion diseases are neurodegenerative disorders caused by abnormally folded prion proteins in central nervous system, which can be detected using the quaking induced conversion assay. Because the assay is extremely sensitive comparing with bioassay, the distribution of the prion in patients diagnosed as sporadic form of Creutzfeldt-Jakob disease, at autopsy was examined. Although it has been regard as infectivity can be restricted within central nervous system in case of sporadic form, we found that the prion activities reach at up to 105-7/g of 50% seeding dose in non-neuronal tissues, suggesting that infectious prions exist in various organs.
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| Free Research Field |
神経変性疾患
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