2017 Fiscal Year Final Research Report
Molecular mechanism for modulation of neural stem cell activity by neuro-immune interaction
| Project/Area Number |
16K18394
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Neurochemistry/Neuropharmacology
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| Research Institution | Osaka University |
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Principal Investigator |
Tanabe Shogo 大阪大学, 医学系研究科, 特任助教(常勤) (40772166)
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Keywords | 神経発生 / オリゴデンドロサイト |
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| Outline of Final Research Achievements |
It has considered that immune system is a major contributor to proliferation and differentiation of neural stem cells during brain development. However, molecular mechanism of neural stem cell modulation by immune system remains unclear. In this study, I investigate the role of immune cells in brain development. I examined the subtype and amount of immune cells in developing brain, and found that B-1 cells are abundant in neonatal brain. B-1 cells mediate oligodendrocyte development and myelination of axons by producing natural antibody.
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| Free Research Field |
神経科学
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