Assessment of fecal microbiota transplantation therapy using spontaneous disease models of common marmosets

2017 Fiscal Year Final Research Report

• Project/Area Number: 16K18407
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Laboratory animal science
• Research Institution: Central Institute for Experimental Animals
• Principal Investigator: INOUE Takashi 公益財団法人実験動物中央研究所, マーモセット研究部, 室長 (60465937)
• Research Collaborator: NOZU Ryoko ; SATO Kenya ; SASAKI Emi
• Project Period (FY): 2016-04-01 – 2018-03-31
• Keywords: マーモセット / FMT / 腸内細菌 / Clostridium difficile

Outline of Final Research Achievements

Therapeutic effect of fecal microbiota transplantation (FMT) was assessed using common marmosets as a nonhuman primate model. FMT therapy resulted in ameliorating diarrhea, weight loss, hypoalbuminemia and anemia in some chronic diarrhea cases of marmosets. FMT also tended to cure recurrent Clostridium difficile infection in marmosets. Analysis of fecal bacterial flora based on the 16S rRNA gene showed shifts of bacterial composition in the animals after FMT, implying that FMT therapy cured dysbiosis related to these intestinal diseases.

Free Research Field

実験動物学、獣医学