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2017 Fiscal Year Final Research Report

Functional Analysis of transcription factor SOX10 in melanoma for norvel therapeutics

Research Project

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Project/Area Number 16K18413
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Tumor biology
Research InstitutionUniversity of Toyama

Principal Investigator

Yokoyama Satoru  富山大学, 和漢医薬学総合研究所, 助教 (90613498)

Project Period (FY) 2016-04-01 – 2018-03-31
Keywordsmelanoma
Outline of Final Research Achievements

The number of melanoma patients is gradually increasing in Japan, and the prognosis is very poor with a 5-year survival rate of less than 20% in the case of metastatic melanoma. In addition, the chemotherapy and radiotherapy are not effective in melanoma; therefore, a new therapeutic strategy is required. In this study, we performed the functional analysis of transcription factor, SOX10, which is highly expressed in melanoma.
Under this research project, we identified 1) the regulation mechanism of PD-L1 in lung cancer, and 2) the induction of apoptosis by Coptidis Rhizoma through BAX/BAK in melanoma.

Free Research Field

腫瘍生物学

URL: 

Published: 2019-03-29  

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