2017 Fiscal Year Final Research Report
Adoptive cell transfer of WT1-specific T cell established by iPS technology
| Project/Area Number |
16K18450
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Tumor therapeutics
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| Research Institution | Kyoto University |
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Principal Investigator |
TAKAHASHI Ryo 京都大学, 医学研究科, 客員研究員 (80571455)
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Keywords | がん免疫療法 / 大腸癌 |
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| Outline of Final Research Achievements |
The aim of this study is to investigate whether the cancer antigen-specific cytotoxic T cells (CTLs) established by iPS technology could eliminate colorectal cancer. Mature CTLs regenerated by specific iPS cells were established from specific T cells for cancer antigen WT-1. We found that the mature CTLs could induce apoptosis of colorectal cancer cell lines (SW480, SW620, T84). Currently, we are investigating this effect using CTOS (cancer tissue-originated spheroid) cells established from surgical resection specimens.
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| Free Research Field |
消化器外科
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