2017 Fiscal Year Final Research Report
Role of Histidine methylation by METTL9
| Project/Area Number |
16K18476
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Medical genome science
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| Research Institution | Institute of Physical and Chemical Research |
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Principal Investigator |
Shimazu Tadahiro 国立研究開発法人理化学研究所, 眞貝細胞記憶研究室, 専任研究員 (10618771)
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Keywords | タンパク質翻訳後修飾 / メチル化 |
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| Outline of Final Research Achievements |
METTL9 is a mitochondrial methyltransferase whose biological functions remain to be uncovered. The applicant has found that METTL9 methylates a specific histidine residue. METTL9 KO mice were generated with CRISPR-Cas9, and their phenotypes including metabolic change was studied. Metabolic change in METTL9 knockdown cells were observed as well.
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| Free Research Field |
エピジェネティクス
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