2017 Fiscal Year Final Research Report
Chemical biology of small RNA chromatin modifiers
| Project/Area Number |
16K18496
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Molecular biology
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| Research Institution | Institute of Physical and Chemical Research |
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Principal Investigator |
Schneider Tilman 国立研究開発法人理化学研究所, 吉田化学遺伝学研究室, 研究員 (30599478)
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| Project Period (FY) |
2016-04-01 – 2018-03-31
|
| Keywords | Chemical Biology / Splicing |
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| Outline of Final Research Achievements |
Splicing inhibition with the small molecule SSA leads to a small RNA-dependent increase in heterochromatin. High throughput sequencing displayed an increase in histone methylation. However, a close association with novel small RNA sequences could not be confirmed. Data refinement and partial re-sequencing is ongoing.
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| Free Research Field |
Chemical Biology
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