Analysis of intestinal environmental change by intake of fructooligosaccharide in the ultra-short term

2017 Fiscal Year Final Research Report

• Project/Area Number: 16K18710
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Food science
• Research Institution: Institute of Physical and Chemical Research
• Principal Investigator: Kato Tamotsu 国立研究開発法人理化学研究所, 統合生命医科学研究センター, 特別研究員 (20632946)
• Project Period (FY): 2016-04-01 – 2018-03-31
• Keywords: 腸内細菌

Outline of Final Research Achievements

Fructooligosaccharides (FOS), one of the prebiotics, has been reported to increase the amount of fecal IgA in mice. To investigate the mechanism of prebiotics influencing to the host, feces were collected every several hours after FOS intakes and the change in intestinal environment was analyzed. Intake of FOS changed microbiota composition in several hours and then changed metabolic profiles. The amount of fecal IgA which is a reaction from the host occurred after the change in the intestinal environment.
As a result, we showed a part of the mechanism that the change of microbiota influence to the host.

Free Research Field

腸内細菌学