2019 Fiscal Year Final Research Report
The establishment for trypanocidal mechanism evaluation assay and application for the development for trypanocidal drugs
| Project/Area Number |
16K18793
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Veterinary medical science
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| Research Institution | Obihiro University of Agriculture and Veterinary Medicine |
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Principal Investigator |
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| Project Period (FY) |
2016-04-01 – 2020-03-31
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| Keywords | トリパノソーマ / 治療薬 |
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| Outline of Final Research Achievements |
Human and Animal African trypanosomosis is a neglected tropical disease and causes severe human and economic loss in developing countries. For controlling the disease, development for novel trypanocidal drugs is an urgent issue. In this study, in vitro trypanicidal activity evaluation assays against six pathogenic trypanosomes were developed and trypanicidal activity about 1,000 compounds were evaluated the assays. In addition, to reveal the mode of trypanocidal action of these compounds, transcriptome analyses were also performed. Several compounds showed strong trypaniocidal activity in vitro, and some of them also showed treatment efficacy using in vivo mice model. The development and implementation for novel trypanocidal drugs against trypanosomosis will be expected based on the current study.
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| Free Research Field |
寄生虫病学
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| Academic Significance and Societal Importance of the Research Achievements |
本研究の学術的意義は、ヒトトリパノソーマ症に比べ研究開発が遅れている動物トリパノソーマ症に対する新規薬剤開発のためのin vitro抗トリパノソーマ活性評価系及び動物試験系を確立し、15報の治療薬候補に関する論文を発表したことである。さらにゲノム情報が不十分であった媾疫トリパノソーマのゲノムと遺伝子発現情報を解析し、今後の治療薬開発研究に用いる基礎的な情報を得たことである。
また社会的意義として、研究過程でトリパノソーマ症汚染国の発展途上国由来の薬用植物成分の抗トリパノソーマ活性を明らかにしたことで、発展途上国において自国の天然資源を用いたトリパノソーマ症治療薬開発の可能性を提示したことである。
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