Spatial-Temporal profile of ultrasound-mediated cisplatin delivery

2017 Fiscal Year Final Research Report

• Project/Area Number: 16K18799
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Veterinary medical science
• Research Institution: Hokkaido University
• Principal Investigator: SASAKI Noboru 北海道大学, 獣医学研究科, 助教 (00754532)
• Project Period (FY): 2016-04-01 – 2018-03-31
• Keywords: 超音波治療 / ドラッグデリバリー / 細胞内薬剤濃度

Outline of Final Research Achievements

Ultrasound-triggered microbubble cavitation is a promising tool for drug and gene delivery in cancer therapy. We evaluated the temporal and spatial profile of cisplatin delivery by ultrasound-triggered microbubble cavitation. We used a bladder cancer mimicking 3D culture model for this study. Single treatment of ultrasound-triggered microbubble cavitation increased an intracellular concentration of cisplatin at the thickness of 100 μm. The duration of enhanced delivery was 1 hr. Based on the distance and duration of delivery, we further tested the feasibility of repetition of the treatment. Triple treatment increased the effective distance by 2-fold. Our results clearly showed spatial and temporal profile of delivery by ultrasound-triggered microbubble cavitation in a tumor-mimicking structure. The results of this study suggest that ultrasound-triggered microbubble cavitation can be repeatable and is promising for cancer treatment.

Free Research Field

獣医学