2017 Fiscal Year Final Research Report
Development of catalytic cyclization and sequential cross-coupling reaction by utilizing the feature of chemical elements
| Project/Area Number |
16K18841
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Chemical pharmacy
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| Research Institution | The University of Tokyo |
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Principal Investigator |
Saito Tatsuo 東京大学, 大学院薬学系研究科(薬学部), 助教 (40612065)
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Keywords | ポリエーテル / 環化反応 / マイトトキシン / 天然物合成 / DFT計算 |
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| Outline of Final Research Achievements |
We have developed an efficient regioselective formation of six-/seven-membered cyclic ethers based on gold-catalyzed intramolecular hydroalkoxylation. We demonstrated sequential cyclization/cross-coupling reactions to afford polycyclic ethers. Furthermore, stereoselective synthesis of the ent-ZA′B′C′D′-ring system of maitotoxin has been accomplished through a convergent strategy utilizing Suzuki－Miyaura cross coupling reaction.
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| Free Research Field |
有機化学
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