2017 Fiscal Year Final Research Report
A synthesis of fluorinated peptide as a biochemical tool toward the analysis of sterically interaction for the peptide
Project/Area Number |
16K18855
|
Research Category |
Grant-in-Aid for Young Scientists (B)
|
Allocation Type | Multi-year Fund |
Research Field |
Chemical pharmacy
|
Research Institution | Setsunan University |
Principal Investigator |
|
Research Collaborator |
GODA Mitsuhiro
KOBAYASHI Naoki
|
Project Period (FY) |
2016-04-01 – 2018-03-31
|
Keywords | フッ素 / ジフルオロ-β-ラクタム / 人工ペプチド / β-アミノ酸 |
Outline of Final Research Achievements |
I studied a synthesis of artificial peptide including fluorinated β-amino acid as a non-proteinogenic amino acid and focused on the utility of fluorinated peptides as a functionalized peptide using the property of fluorine substituents. The construction of the desired peptide was realized by the ring-opening reaction of a highly electrophilic difluoro-β-lactam with amino acid without a condensation reagent in trifluoroethanol. Unfortunately, the evaluation of functionality for sterically interaction of the fluorinated peptide could not be achieved. However, the obtaining peptides showed the tolerance for enzymatic hydrolysis.
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Free Research Field |
有機フッ素化学
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