2017 Fiscal Year Final Research Report
The mechanism of novel LPA3-mediated activation of vagal afferent nerve
| Project/Area Number |
16K18870
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Biological pharmacy
|
|---|
| Research Institution | Tohoku University |
|---|
Principal Investigator |
Kano Kuniyuki 東北大学, 薬学研究科, 助教 (50636404)
|
|---|
| Project Period (FY) |
2016-04-01 – 2018-03-31
|
| Keywords | リゾホスファチジン酸 / 迷走神経 / 心筋梗塞 |
|---|
| Outline of Final Research Achievements |
Imaging MS and LC-MS/MS analysis revealed that lysophosphatidic acid (LPA) containing docosahexaenoic acid (DHA (22:6)) was selectively elevated in the ischemic heart. Administration of autotaxin (ATX) inhibitor did not affect the increase of DHA-LPA, suggesting that DHA-LPA was produced in ATX-independent manner.
LPA3 agonist induced a transient apnea and a prolonged hypopnea, which is resulted from activation of vagus nerve. We also found novel pharmacological action of LPA3 agonist independent on vagus nerve.
|
| Free Research Field |
生理活性脂質
|
