2017 Fiscal Year Final Research Report
Mechanisms of induction of mucosal immunity by adenovirus vector vaccine
| Project/Area Number |
16K18873
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Biological pharmacy
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| Research Institution | Osaka University |
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Principal Investigator |
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Keywords | アデノウイルスベクター / 粘膜ワクチン / Th17 / Type I IFN / 炎症性樹状細胞 / 炎症性単球 |
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| Outline of Final Research Achievements |
Few of the current vaccines can induce antigen (Ag)-specific immunity in both mucosal and systemic compartments. Hence, the development of vaccines that realize both protections against various pathogens is a high priority in global health. It was reported that intramuscular vaccination of an adenovirus vector (Adv) can induce Ag-specific cytotoxic T lymphocytes (CTLs) in both systemic and gut-mucosal compartments. We previously revealed that type I IFN signaling is required for the induction of gut-mucosal, not systemic, CTLs, following the vaccination. Here, we revealed that type I IFN is required for the induction of Ag-specific Th17 cells, which could promote the induction of Ag-specific CTLs selectively in the gut mucosa. These data suggested that Th17 cells translate systemic type I IFN into gut-mucosal CTL response following the vaccination. Our findings should lead to the development of promising Adv vaccines that can establish both systemic and gut-mucosal protective immunity.
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| Free Research Field |
免疫学、分子細胞生物学
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