2018 Fiscal Year Final Research Report
Application of PRMT5 targeted pharmacological therapy for heart failure
| Project/Area Number |
16K18876
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Biological pharmacy
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| Research Institution | University of Shizuoka |
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Principal Investigator |
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| Project Period (FY) |
2016-04-01 – 2019-03-31
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| Keywords | アルギニンメチル化酵素 / 心肥大 / 心不全 / エピジェネティクス |
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| Outline of Final Research Achievements |
We investigate the potential of heart failure therapy targeting PRMT5. Pressure overload-induced cardiac hypertrophy and heart failure are suppressed by treatment with PRMT5 inhibitor. PRMT5 enhances p300 histone acetyltransferase activity in heart. These results indicate that PRMT5 is a possible molecular target for heart failure therapy.
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| Free Research Field |
生物系薬学
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| Academic Significance and Societal Importance of the Research Achievements |
本研究成果は、世界で初めてアルギニンメチル化酵素を標的とする心不全薬物療法の可能性を示した。これは学術的にはもちろん、いまだ十分とは言えない心不全薬物治療の新たな可能性を示しており、社会的意義も大きいと考える。
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