The involvement of epigenetic regulation of GABAB1a in the pathophygiologies

2017 Fiscal Year Final Research Report

• Project/Area Number: 16K18891
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Pharmacology in pharmacy
• Research Institution: Setsunan University
• Principal Investigator: ARAKI Ryota 摂南大学, 薬学部, 助教 (90710682)
• Project Period (FY): 2016-04-01 – 2018-03-31
• Keywords: エピジェネティクス / セロトニン / GABA / 環境要因

Outline of Final Research Achievements

Our previous studies have implied the possibility that epigenetic modification-induced abnormal regulation of neuronal excitability in the dorsal raphe nucleus may cause environmental factor-induced psychiatric disorders. In this study, we showed that alterations of the expression and epigenetic modification in GABA/5-HTergic neuron-related genes in the dorsal raphe nucleus of social defeat stress model mice. Furthermore, we also found the alterations of the prefrontal 5-HTergic function in the social defeat stress model mice. These transcriptional and neurochemical alterations may be involved in the environmental factor-induced psychological dysfunctions.

Free Research Field

神経精神薬理