2017 Fiscal Year Final Research Report
The involvement of epigenetic regulation of GABAB1a in the pathophygiologies
Project/Area Number |
16K18891
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Pharmacology in pharmacy
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Research Institution | Setsunan University |
Principal Investigator |
ARAKI Ryota 摂南大学, 薬学部, 助教 (90710682)
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Project Period (FY) |
2016-04-01 – 2018-03-31
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Keywords | エピジェネティクス / セロトニン / GABA / 環境要因 |
Outline of Final Research Achievements |
Our previous studies have implied the possibility that epigenetic modification-induced abnormal regulation of neuronal excitability in the dorsal raphe nucleus may cause environmental factor-induced psychiatric disorders. In this study, we showed that alterations of the expression and epigenetic modification in GABA/5-HTergic neuron-related genes in the dorsal raphe nucleus of social defeat stress model mice. Furthermore, we also found the alterations of the prefrontal 5-HTergic function in the social defeat stress model mice. These transcriptional and neurochemical alterations may be involved in the environmental factor-induced psychological dysfunctions.
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Free Research Field |
神経精神薬理
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