2017 Fiscal Year Final Research Report
Approach to drug discovery of microbial inhibitors of lipid metabolism
| Project/Area Number |
16K18900
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Natural medicines
|
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| Research Institution | Kitasato University |
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Principal Investigator |
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| Project Period (FY) |
2016-04-01 – 2018-03-31
|
| Keywords | 天然物 / 脂質代謝 / 動脈硬化 / 脂肪肝 / ケミカルバイオロジー |
|---|
| Outline of Final Research Achievements |
In this study, 1) screening for microbial inhibitors of lipid metabolism (neutral lipids; cholesteryl ester (CE) and triglyceride (TG)), 2) in vivo test of pyripyropene A derivative, highly SOAT2 selective inhibitor, using a mouse model of fatty liver diseases (NAFLD/NASH) and 3) search for the mode of action of new microbial inhibitors of lipid metabolism (from 1)) and beauveriolide III, SOAT1-selective inhibitor in intact cells, using biochemistry techniques were investigated.
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| Free Research Field |
天然物化学
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