Development of signal amplification probes for detection of Copper (II) ions Using 11B NMR/MRI

2017 Fiscal Year Final Research Report

• Project/Area Number: 16K18915
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Drug development chemistry
• Research Institution: The Noguchi Institute
• Principal Investigator: Tanaka Tomohiro 公益財団法人野口研究所, 研究部, 研究員 (20711667)
• Project Period (FY): 2016-04-01 – 2018-03-31
• Keywords: ホウ素MRI / カルボラン / 銅(II)イオン

Outline of Final Research Achievements

Biorelevant metals have been known to play an important role for bio-organism. Specifically, Cu2+ ion is closely correlated with certain types of physiological and pathological events. Therefore, the development of a noninvasive methodology for detecting Cu2+ is important for understanding its biological role and relationship with disease. Herein, we report on the development of a Cu2+‐specific 11B NMR/MRI probe. The method is based on the rapid complete deboronation reaction of nido-o-carborane containing a chelator unit by Cu2+ under physiological conditions.

Free Research Field

薬学