2017 Fiscal Year Final Research Report
Role of reactive sulfur species as a key molecule to diminish toxicity of methylmercury in mice
| Project/Area Number |
16K18919
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Environmental and hygienic pharmacy
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| Research Institution | University of Tsukuba |
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Principal Investigator |
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Keywords | メチル水銀 / 活性イオウ分子 |
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| Outline of Final Research Achievements |
Methylmercury (MeHg) is an environmental electrophile that readily modifies protein thiols, causing toxicity. MeHg is inactivated by sulfur nucleophiles such as cysteine (CysSH), glutathione (GSH) and its related reactive persulfides (RSS) through the formation of GSH adduct (MeHg-SG) and bismethylmercury sulfide ((MeHg)2S), respectively. Cystathionine g-lyase (CSE) catalyzes production of CysSH and RSS. Previously, we revealed that CSE deletion in mice caused decreased levels of sulfur nucleophiles including GSH and RSS due to the disruption of CysSH metabolism, resulting in increased sensitivity to MeHg
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| Free Research Field |
環境生物学
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