2017 Fiscal Year Final Research Report
Research on detoxification mechanism of environmental electrophiles mediated by reactive sulfur species
| Project/Area Number |
16K18920
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Environmental and hygienic pharmacy
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| Research Institution | University of Tsukuba |
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Principal Investigator |
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Keywords | 活性イオウ分子 |
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| Outline of Final Research Achievements |
Environmental electrophiles such as 1,4-napthoquinone (1,4-NQ) and methylmercury easily bind to the protein thiols, thereby inducing cytotoxicity. In this study, we investigated the cytoprotective roles of reactive sulfur species, a highly nucleophilic compounds. We found that exposure of primary mouse hepatocytes to polysulfide and 1,4-NQ markedly decreased 1,4-NQ-mediated cell death and S-arylation of cellular proteins. Activation of cell survival signaling under exposure to 1,4-NQ was suppressed in the presence of polysulfides. These results suggest that reactive sulfur species act as a initial cytoprotective factor by capturing this electrophile.
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| Free Research Field |
環境衛生学
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