2017 Fiscal Year Final Research Report
Interactive analysis of medicines with food constituent using surface plasmon resonance
| Project/Area Number |
16K18970
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Medical pharmacy
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| Research Institution | Mukogawa Women's University |
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Principal Investigator |
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Keywords | SPR / bitter / taste |
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| Outline of Final Research Achievements |
The purpose of this study was to evaluate the interaction between bitter drugs and taste masking agents derived from food constituents. Chlorogenic acid (CGA) is known to be present in fruits, vegetables and coffee in high concentrations, and its safety is assured. We firstly measured the bitterness of six different bitter drugs. Taste sensor outputs were significantly inhibited by the addition of CGA to all drugs. The interaction between the bitter drugs and CGA was investigated by SPR analysis using SPR-Navi 200 (BioNavis). SPR kinetic analysis of the results was performed with TraceDrawer form BioNavis. The inhibition rasios (%) of the taste sensor output of bitter drugs caused by CGA and the association rate constant between the drugs and CGA were significantly correlated. It was suggested that the taste-masking effect of CGA are due to its direct association with the drugs. CGA may therefore be useful taste-masking agent for basic drugs.
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| Free Research Field |
医療薬学
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