2017 Fiscal Year Final Research Report
Investigating the regulation of GnRH neurons in the neuroinflammation
| Project/Area Number |
16K18984
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
General anatomy (including histology/embryology)
|
|---|
| Research Institution | Hyogo Medical University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2016-04-01 – 2018-03-31
|
| Keywords | GnRHニューロン / 炎症性サイトカイン |
|---|
| Outline of Final Research Achievements |
We focused on the relationship between inflammatory cytokines and neuroendocrine cells, and identified IL-18Rα-expressing and IL-18-expressing cells in the male mouse and rat forebrain. IL-18Rα was expressed in approximately 60 % of GnRH-immunopositive perikarya, and IL-18 was distributed in all GnRH-immunopositive perikarya. We next confirmed the expression of IL-18 and its receptor in GT1-7 cells, a GnRH-producing cell line. We also detected the expression of other inflammatory cytokines, TNF-α, IL-1β and IL-6, and their receptors in GT1-7 cells. Our observations indicate that these inflammatory cytokines may exert direct effects upon GnRH neurons via their specific receptors. There is a possibility that these cytokines regulate the function of GnRH neurons in an autocrine or paracrine manner.
|
| Free Research Field |
神経内分泌学
|
