The neurophysiological analysis of neuronal type selective in the circadian clock

2017 Fiscal Year Final Research Report

• Project/Area Number: 16K19005
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Environmental physiology(including physical medicine and nutritional physiology)
• Research Institution: University of Tsukuba
• Principal Investigator: HASEGAWA Emi 筑波大学, 国際統合睡眠医科学研究機構, 助教 (40765955)
• Project Period (FY): 2016-04-01 – 2018-03-31
• Keywords: 中枢概日時計 / 視交叉上核（SCN） / 電気生理学的特性 / GABA受容体

Outline of Final Research Achievements

We have researched to clarify neuronal activity and electrophysiological characteristics, diurnal variation of AVP (arginine vasopressin) neurons, VIP (vasoactive intestinal peptide) neurons in the circadian clock / suprachiasmatic nucleus (SCN) by using the brain slice of normal mouse and neuron type specific mutant mouse. In this research project, we found that the GABA receptor is involved in the diurnal variation of neural activity in SCN. In addition, the change in neuronal activity by the responsiveness of GABA receptor was different depending on each neuron.

Free Research Field

神経科学