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2017 Fiscal Year Annual Research Report

Beneficial role of plasmalogens in the brain which are reduced by ageing, stress and neuroinflammation

Research Project

Project/Area Number 16K19007
Research InstitutionKyushu University

Principal Investigator

Hossain Shamim  九州大学, 医学研究院, 准教授 (40647707)

Project Period (FY) 2016-04-01 – 2018-03-31
KeywordsPlasmalogens / glial activation / neurotrophic factor / memory / Hippocampus
Outline of Annual Research Achievements

In my two-years study, I observed that Plasmalogens (Pls) improved hippocampal dependent memory in mice by activating the BDNF and TrkB signaling (paper under revision). Oral ingestion of Pls attenuated the lipopolysaccharide-induced glial activation and amyloid beta (Aβ) deposition in the mice resulting in the cognition improvement (Hossain MS et al., BBRC, 2018). I also clarified of how these lipids are reduced in the brain by aging, stress and inflammation via the NF-kB and c-Myc pathways (Hossain MS et al., J Neurosci., 2017). A possible functional interaction of Pls with some nuclear receptors and orphan G-protein coupled receptor (GPCR) proteins was also observed, which might help us to understand the diverse role of Pls in our health. In addition, I also observe the epigenetic regulation of neurotrophic factors in the murine brain to better understand the memory process (Hossain et al., Mol. Neurobio., 2017).

  • Research Products

    (4 results)

All 2018 2017

All Journal Article (2 results) (of which Peer Reviewed: 2 results,  Open Access: 2 results) Presentation (2 results)

  • [Journal Article] Oral ingestion of plasmalogens can attenuate the LPS-induced memory loss and microglial activation.2018

    • Author(s)
      Hossain MS, Tajima A, Kotoura S, Katafuchi T
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 496(4) Pages: 1033-1039

    • DOI

      10.1016/j.bbrc.2018.01.078

    • Peer Reviewed / Open Access
  • [Journal Article] Glucose can epigenetically alter the gene expression of neurotrophic factors in the murine brain cells.2017

    • Author(s)
      Hossain MS,Oomura Y,and Katafuchi T
    • Journal Title

      Molecular Neurobiology

      Volume: 55(4) Pages: 3408-3425

    • DOI

      10.1007/s12035-017-0578-3

    • Peer Reviewed / Open Access
  • [Presentation] Glucose-induced cell specific expression of BDNF and FGF-1 in the mouse hippocampus:an involvement of epigenetic modifications2017

    • Author(s)
      Yutaka Oomura,Shamim M.Hossain,Toshihiko Katafuchi
    • Organizer
      第40回 日本神経科学大会
  • [Presentation] Reduction of Ether-type Glycerophospholipids,Plasmalogens,in the Mouse Hippocampus induced by Inflammatory Signals,Aging and Chronic Stress2017

    • Author(s)
      Toshihiko Katafuchi,Shamim M.Hossain
    • Organizer
      第40回 日本神経科学大会

URL: 

Published: 2018-12-17  

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