Mechanism of astrocyte-mediated ischemic tolerance

2017 Fiscal Year Final Research Report

• Project/Area Number: 16K19016
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: General pharmacology
• Research Institution: University of Yamanashi
• Principal Investigator: HIRAYAMA Yuri 山梨大学, 医学部附属病院, 薬剤師 (30732804)
• Project Period (FY): 2016-04-01 – 2018-03-31
• Keywords: グリア細胞 / アストロサイト / 脳梗塞 / 虚血耐性 / ATP受容体

Outline of Final Research Achievements

Brain ischemic tolerance is an endogenous neuroprotective mechanism, whereby an experience of mild ischemic episode (preconditioning; PC) produces resilience to subsequent much severe ischemic injury. We previously showed that PC-induced activation of astrocytes, and their subsequent expression of HIF-1α is responsible for ischemic tolerance. Although PC also increased HIF-1α in neurons, this was not involved in ischemic tolerance. Here, we show the difference in mechanism of HIF-1α increase between neurons and astrocytes, and answer why astrocytic HIF-1α is more important.

Free Research Field

神経薬理学