2017 Fiscal Year Final Research Report
Functional analysis of long noncoding RNAs that regulate epithelial-mesenchymal transition
| Project/Area Number |
16K19030
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
General medical chemistry
|
|---|
| Research Institution | Kanazawa University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2016-04-01 – 2018-03-31
|
| Keywords | 上皮間葉転換 / EMT / 長鎖非コードRNA / lncRNA / ポリコーム抑制複合体 / PRC2 |
|---|
| Outline of Final Research Achievements |
We have focused on epithelial-mesenchymal transition (EMT) as a mechanism of cancer progression and reported that polycomb repressive complex 2 (PRC2), which is one of epigenetic regulators, induces EMT by repressing the expression of epithelial genes. In this study, we proposed that MEG3 long noncoding RNA guides PRC2 to its target gene loci. These results contribute to understanding of long noncoding RNA involved in cancer progression.
|
| Free Research Field |
分子生物学
|
