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2018 Fiscal Year Final Research Report

Growth cone reformation in the axon regeneration

Research Project

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Project/Area Number 16K19032
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field General medical chemistry
Research InstitutionNagoya University

Principal Investigator

li chun  名古屋大学, 高等研究院(理), 特任助教 (40755716)

Project Period (FY) 2016-04-01 – 2019-03-31
Keywords神経再生 / 線虫C.elegans
Outline of Final Research Achievements

1.We found that LET-502-MLC-4-NMY-2 pathway regulated growth cone reformation in the axon regeneration. 2.We found that SVH-16, a CDK type protein kinase might have function in the upstream of JNK pathway or parallel to JNK pathway. 3. We found that C.elegans homolog ATN-1, actinin alpha 1 can bind to ALP-1, an ortholog of human LDB3 (LIM domain binding 3), which had important function in the axon regeneration.

Free Research Field

分子生物学

Academic Significance and Societal Importance of the Research Achievements

神経軸索の再生機構の解明は、医学的には事故や疾患による神経切断や欠損の治療法を開発する上で重要であり、社会的にも喫緊の研究課題である。従って、本研究は単なる学術的発見にとどまらず、ヒトにおける神経再生誘導の理解および再生治療に繋がることが期待される点で、日本発の極めて重要な研究と考える。

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Published: 2020-03-30  

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