Identification and functional analysis of a novel Nectin-mediated cell-adhesion apparatus

2017 Fiscal Year Final Research Report

• Project/Area Number: 16K19035
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: General medical chemistry
• Research Institution: Kyoto University
• Principal Investigator: Maruoka Masahiro 京都大学, 物質－細胞統合システム拠点, 特定助教 (70736412)
• Project Period (FY): 2016-04-01 – 2018-03-31
• Keywords: ネクチン / 細胞間接着 / シグナル伝達

Outline of Final Research Achievements

The aim of this study is to undestand the role of Nectin-mediated cell-adhesion apparatus in mammary gland and to identify a novel Nectin-mediated cell-adhesion apparatus that contributes to the formation of functional tissue architecture other than mammary glands. I demonstrated that the Nectin-mediated cell-adhesion apparatus in the mammary gland interacts with the prolactin receptor essential for mammary gland development during pregnancy, thereby promoting the prolactin receptor signaling and revealed its molecular mechanism. In addition, using reporter mice that can visualize the expression of nectinｓ, I identified a novel nectin-dependent cell adhesion apparatus.

Free Research Field

分子細胞生物学