Elucidation of mechanisms for metabolic disorder and chronic inflammation by S-nitrosylation, a novel protein modification after translation.

2017 Fiscal Year Final Research Report

• Project/Area Number: 16K19048
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Pathological medical chemistry
• Research Institution: Tokyo Medical and Dental University
• Principal Investigator: SHINOZAKI Shohei 東京医科歯科大学, 大学院医歯学総合研究科, 非常勤講師 (40622626)
• Project Period (FY): 2016-04-01 – 2018-03-31
• Keywords: 糖尿病 / インスリン抵抗性 / メタボリックシンドローム / S-ニトロソ化 / iNOS / 一酸化窒素

Outline of Final Research Achievements

In this study, we focused on the development of age-related diseases, including metabolic syndrome, diabetes and arteriosclerosis. To clarify relationships between metabolic reprogramming and protein S-nitrosylation, we studied about 1) DNA and histone methylation / demethylation enzymes; 2) GSNOR-KO mice; 3) natural compounds which inhibit protein S-nitrosylation and/or iNOS.
Within this study period, 1) we identified novel S-nitrosylated DNA and histone methylation / demethylation enzymes. 2) In GSNOR-KO mice, it was revealed that S-nitrosylation affects diabetes and obesity. 3) Natural compounds, derived from food, inhibit S-nitrosylation are identified and confirmed beneficial effects of diabetes.

Free Research Field

糖尿病、動脈硬化