2017 Fiscal Year Final Research Report
Identification of new beta-catenin target genes using genome-wide analyses of chromatin structure
| Project/Area Number |
16K19075
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Human pathology
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| Research Institution | The University of Tokyo |
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Principal Investigator |
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Keywords | 肝細胞癌 / ゲノム / エピゲノム / FAIRE |
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| Outline of Final Research Achievements |
Itis known that not only genetic changes but also epigenetic alterations are important for the genesis and prognosis of cancer. In this project, we focused on beta-catenin (CTNNB1) mutations in hepatocellular carcinoma and revealed how these beta-catenin mutations affect the chromatin structure using integrated genome-wide analyses. Briefly we detected changes in chromatin structure, which were specific to the beta-catenin mutations. Finally we identified novel direct targets of beta-catenin, which might be candidates for therapeutic targets.
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| Free Research Field |
肝細胞癌
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