Prognostic factors of dedifferentiated liposarcoma detected using custom CGH array.

2018 Fiscal Year Final Research Report

• Project/Area Number: 16K19079
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Human pathology
• Research Institution: Japanese Foundation for Cancer Research (2018); Nagoya University (2016-2017)
• Principal Investigator: Yamashita Kyoko 公益財団法人がん研究会, がん研究所 病理部, 研究員 (50754975)
• Project Period (FY): 2016-04-01 – 2019-03-31
• Keywords: 脱分化型脂肪肉腫 / カスタムCGHアレイ / 予後因子

Outline of Final Research Achievements

For the purpose of clarifying the factors related to the distant metastasis and poor prognosis in dedifferentiated liposarcoma, array CGH analysis and clinicopathological analysis were performed. We used a custom CGH　array, which included dense coverage for genes in the areas known to be frequently amplified in　dedifferentiated liposarcoma. As a result, High MDM2/HMGA2 ration in array CGH and histological grade, cellular atypia and MDM2 immunoreactivity in pathological analysis proved to be important prognostic factors.

Free Research Field

pathology

Academic Significance and Societal Importance of the Research Achievements

本研究によって明らかになった予後予測因子は、個々の患者の予後予測に有用であるばかりでなく、MDM2/HMGA2比が予後と関連するという結果は、脱分化型脂肪肉腫の病態解明の一助となり、また免疫染色上MDM2の発現が高いほど予後不良であるという結果は、治療薬の開発にも糸口を提供するものである。