Development of hormone-dependent salivary cancer therapy based on the comprehensive understanding of androgen receptor

2017 Fiscal Year Final Research Report

• Project/Area Number: 16K19090
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Human pathology
• Research Institution: Fujita Health University
• Principal Investigator: Sakurai Kouhei 藤田保健衛生大学, 医学部, 助教 (10608756)
• Project Period (FY): 2016-04-01 – 2018-03-31
• Keywords: 唾液腺導管癌 / 転写因子 / FOXA1 / マイクロアレイ

Outline of Final Research Achievements

The purpose of this study is to reveal the molecular pathogenesis of salivary duct carcinoma (SDC). SDC, an androgen receptor (AR)-positive malignancy, is a relatively rare salivary cancer characterized by extremely poor outcome. The growth of SDC is reported to be androgen dependent. Although androgen deprivation therapy (ADT) might be effective in SDC based on its effect on other AR-expressing cancers, such as prostate cancer (PCa) and apocrine carcinoma of the breast (ACB), its detailed gene expression signature in SDC is unclear. In this study we compare the gene expressions of SDC, PCa and ACB to reveal their shared and distinct features. We aim to identify novel diagnostic marker and develop therapeutic strategy for SDC.

Free Research Field

分子腫瘍学