2017 Fiscal Year Final Research Report
Clinicopathological significance of PD-L1 expression in peripheral T-cell lymphoma
| Project/Area Number |
16K19093
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Human pathology
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| Research Institution | Kurume University |
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Principal Investigator |
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Keywords | 悪性リンパ腫 / PD-L1 / 腫瘍免疫 / 予後 |
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| Outline of Final Research Achievements |
Programmed cell death ligand 1 (PD-L1) is expressed on both tumor cells and tumor-infiltrating nonmalignant cells in lymphoid malignancies. The PD-1/PD-L1 pathway suppresses host antitumor responses, although little is known about the significance of PD-1/PD-L1 expression in the tumor microenvironment. To investigate the clinicopathological impact of PD-L1 expression in adult T-cell leukemia/ lymphoma(ATLL), we performed PD-L1 immunostaining. Neoplastic PD-L1 (nPD-L1) positive ATLL had inferior overall survival(OS) compared to nPD-L1 negative ATLL. Among nPD-L1 negative ATLL, microenvironmental PD-L1(miPD-L1) positive ATLL showed superior OS compared to PD-L1 negative ATLL. The expression of nPD-L1 and miPD-L1 maintained prognostic value for OS in multivariate analysis.
This is the significant report describing the clinicopathological features and outcomes of PD-L1 expression in ATLL.
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| Free Research Field |
血液病理学
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