The role of sexual hormone in hematological malignancies

2017 Fiscal Year Final Research Report

• Project/Area Number: 16K19095
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Human pathology
• Research Institution: Kurume University
• Principal Investigator: Sasaki Yuya 久留米大学, 医学部, 助教 (50750725)
• Project Period (FY): 2016-04-01 – 2018-03-31
• Keywords: 悪性リンパ腫 / 白血病 / 多発性骨髄腫 / 骨髄増殖性疾患 / 骨髄異形成症候群 / エストロゲンレセプター

Outline of Final Research Achievements

We clinically and pathologically analyzed the expression rate of estrogen receptor alpha and estrogen receptor beta, mainly for diffuse large cell type B cell lymphoma (DLBCL). Furthermore, we analyzed the effect of an estrogen receptor inhibitor on cultured cells derived from DLBCL. As a result, we obtained the result of the effect of the drug, involved in cell cycle arrest through the MAP kinase pathway. This result may lead to new therapeutic development.

Free Research Field

造血器腫瘍 (特に悪性リンパ腫　白血病)