2017 Fiscal Year Final Research Report
The molecular function of TMEPAI in tumorigenesis
| Project/Area Number |
16K19100
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Experimental pathology
|
|---|
| Research Institution | University of Tsukuba |
|---|
Principal Investigator |
|
|---|
| Research Collaborator |
Meidi Utami Puteri
Riezki Amalia
Mohammed Abdelaziz
Bantari Wisynu Kusuma Wardhani
|
|---|
| Project Period (FY) |
2016-04-01 – 2018-03-31
|
| Keywords | 腫瘍形成 / 足場非依存的増殖 / TMEPAI / Wnt |
|---|
| Outline of Final Research Achievements |
TMEPAI is a transmembrane protein that is highly expressed in cancer cells and is known to be involved in tumorigenesis. Several TMEPAI isoforms that possess distinct extra-cellular domain are reported. In this study, we found that the TMEPAI isoform D is strongly expressed in breast cancer cell lines. Therefore, TMEPAI in involved in anchorage-independent growth in breast cancer cells. Moreover, we demonstrated that TMEPAI's novel molecular function that TMEPAI inhibits Wnt signaling pathway.
|
| Free Research Field |
腫瘍生物学
|
