Analysis of association between chronic inflammation and tumorigenesis in skin using psoriasis mouse model

2017 Fiscal Year Final Research Report

• Project/Area Number: 16K19104
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Experimental pathology
• Research Institution: Nagoya University
• Principal Investigator: Mii Shinji 名古屋大学, 医学系研究科, 特任助教 (80646505)
• Project Period (FY): 2016-04-01 – 2018-03-31
• Keywords: CD109 / 皮膚発癌 / 扁平上皮癌 / 炎症性発癌

Outline of Final Research Achievements

In this study, we investigated the role of CD109 in skin tumorigenesis using a two-stage carcinogenesis model in CD109-deficient mice with chronic skin inflammation. Although no significant difference was found in conversion rates from papilloma to carcinoma between wild-type and CD109-deficient mice in the carcinogenesis model, we observed fewer and smaller papillomas in CD109-deficient mice than in wild-type mice. Additionally, immunofluorescence analysis showed that SMAD2 phosphorylation and NRF2 expression were enhanced in primary keratinocytes from CD109-deficient mice compared with in those from wild-type mice.
These results suggest that CD109 deficiency suppresses skin tumorigenesis by enhancing TGF-β/SMAD/NRF2 pathway activity.

Free Research Field

実験病理学