Study on the relationship between the causative Fusarium species of invasive fusariosis and environmental fungal flora

2018 Fiscal Year Final Research Report

• Project/Area Number: 16K19120
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Bacteriology (including mycology)
• Research Institution: Chiba University
• Principal Investigator: Muraosa Yasunori 千葉大学, 真菌医学研究センター, 特任助教 (10574668)
• Research Collaborator: Oguchi Misato ; Hino Yutaro ; Yahiro Maki ; Yarita kyoko ; Watanabe Akira ; Kamei Katsuhiko
• Project Period (FY): 2016-04-01 – 2019-03-31
• Keywords: Fusarium / FSSC / 病原真菌 / 環境調査 / メタゲノム解析

Outline of Final Research Achievements

The objective of this study is to reveal the relationship between the causative Fusarium species of invasive fusariosis and environmental fungal flora and the difference of virulence. F. petroliphilum (a member of the FSSC) was predominately isolated from the patients with invasive fusariosis. It was reveals that F. petroliphilum predominately isolated from the drain ports in the room. In the infection experiments using mice, the weight loss rate at 7 days after infection in the F. petroliphilum infection group was significantly reduced compared to the F. falciforme and the F. oxysporum infection groups. In addition to environmental factors, it was suggested that the virulence of F. petroliphilum was somewhat involved in the development of invasive fusariosis.

Free Research Field

医真菌学

Academic Significance and Societal Importance of the Research Achievements

本邦ではこれまでにフザリウム症原因菌の詳細については調査されてこなかった。本研究ではフザリウム症の原因菌の詳細を明らかにし、本症の新たな基礎知見の集積に貢献した。さらに病室を含む室内の排水口が深在性フザリウム症の感染源として強く疑われることを示した。深在性フザリウム症の多くは病室内での感染が疑われることから、本研究の成果は今後の深在性フザリウム症の感染防除対策に深く寄与するものと考えられる。