Functional analysis of genomic islands in highly multidrug-resistant Pseudomonas aeruginosa

2018 Fiscal Year Final Research Report

• Project/Area Number: 16K19133
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Bacteriology (including mycology)
• Research Institution: Juntendo University (2017-2018); National Center for Global Health and Medicine (2016)
• Principal Investigator: Tada Tatsuya 順天堂大学, 医学部, 准教授 (00624644)
• Research Collaborator: HIRANO Takashi ; SATOU Kazuhito
• Project Period (FY): 2016-04-01 – 2019-03-31
• Keywords: 高度多剤耐性緑膿菌 / ゲノミックアイランド / 薬剤耐性因子 / インテグレーション

Outline of Final Research Achievements

The nosocomial infection due to highly multidrug-resistant Pseudomonas aeruginosa threatens medical security worldwide. Our previous studies on whole genome analysis revealed that highly multidrug-resistant P. aeruginosa strains were disseminated in medical settings while uptaking drug-resistant genes through plasmid horizontally among these pathogens as well as uptaking these genes in the chromosomes. Our present study suggested that specific genes of genomic islands in highly multidrug-resistant P. aeruginosa are not associated with uptaking of outside genes, but the mutations of genes which P. aeruginosa generally harbor will be promote uptaking outside genes.

Free Research Field

微生物学

Academic Significance and Societal Importance of the Research Achievements

高度多剤耐性緑膿菌は日本を含むアジアの医療施設で大きな問題となっている。これらの多剤耐性菌の耐性化にはプラスミドではなく染色体上に薬剤耐性因子を取り込む機構が存在することが示唆されている。この取り込み機構の解明は医療施設で蔓延する緑膿菌の高度耐性化のメカニズムの解明につながり、社会的意義は大きいと考えられる。