2017 Fiscal Year Final Research Report
The mechanisms by which polyI:C enhances IgA production in NALT
| Project/Area Number |
16K19134
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Virology
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| Research Institution | Hokkaido University |
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Principal Investigator |
Ariki Hiromi 北海道大学, 医学研究科, 助教 (40515061)
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Keywords | TLR3 / polyI:C / CD103陽性樹状細胞 / 鼻腔関連リンパ組織 |
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| Outline of Final Research Achievements |
The development of influenza virus prevention vaccines requires the proper selection of appropriate adjuvants. The mechanism by which poly I: C promotes antibody production has not been fully elucidated. PolyI:C is a synthetic analog for double-stranded RNA and intranasal inoculation with polyI:C strongly enhances IgA production in nasal mucosa. To uncover the mechanisms by which intranasal inoculation with polyI:C enhances IgA production, I investigated immune responses in nasal-associated lymphoid tissue after intranasal vaccination.
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| Free Research Field |
免疫学
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