Development of an anti-paramyxovirus drug targeting accessory C protein

2017 Fiscal Year Final Research Report

• Project/Area Number: 16K19140
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Virology
• Research Institution: Hiroshima University
• Principal Investigator: Oda Kosuke 広島大学, 医歯薬保健学研究科(医), 助教 (60571255)
• Project Period (FY): 2016-04-01 – 2018-03-31
• Keywords: ハイスループットスクリーニング / FRET / 抗ウイルス薬 / センダイウイルス / Cタンパク質 / PPI阻害剤

Outline of Final Research Achievements

Sendai virus (SeV) causes respiratory tract infection in mice and used as a prototype of viruses belonging to the family paramyxoviridae. In SeV lacking the C protein, the viral pathogenicity was significantly decreased. C protein associates with STAT1 to escape from the host innate system, and it associates with Alix for efficient viral budding from host cells. It is possible that a compound that inhibits the interaction between C protein and STAT1/Alix will become an antiviral drug against SeV or SeV-related viruses. In this study, we carried out a high-throughput screening assay to find a candidate agent targeting C protein. As the result, some acridone derivatives were found to inhibit the association of C protein with Alix.

Free Research Field

構造生物学