2017 Fiscal Year Final Research Report
The role of inhibitory-type C-type lectin receptors in fungal immunity
Project/Area Number |
16K19147
|
Research Category |
Grant-in-Aid for Young Scientists (B)
|
Allocation Type | Multi-year Fund |
Research Field |
Immunology
|
Research Institution | Chiba University |
Principal Investigator |
Yabe Rikio 千葉大学, 真菌医学研究センター, 助教 (00598229)
|
Research Collaborator |
SAIJO Shinobu
IWAKURA Yoichiro
CHUNG Soo-Hyun
|
Project Period (FY) |
2016-04-01 – 2018-03-31
|
Keywords | 真菌 / 自然免疫受容体 / サイトカイン |
Outline of Final Research Achievements |
C-type lectin receptors are a large family of transmembrane proteins containing extracellular C-type lectin-like carbohydrate-recognition domain(s) and signal transduction region(s), i.e., immunoreceptor tyrosine-based activation motif (ITAM) and immunoreceptor tyrosine-based inhibitory motif (ITIM). Although ITAM-coupling CLRs are best-characterized as direct receptors for fungi, the role of ITIM-bearing CLRs has been poorly understood. In this study, we found that a soluble form of inhibitory-type CLRs bound to Candida species. Furthermore, inhibitory-type CLRs mediated inflammatory cytokine production in macrophages and neutrophils following stimulation with those fungi. These data suggest that inhibitory-type CLRs play an important role in immune responses to fungal infection.
|
Free Research Field |
糖鎖生物学
|