The role of inhibitory-type C-type lectin receptors in fungal immunity

2017 Fiscal Year Final Research Report

• Project/Area Number: 16K19147
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Immunology
• Research Institution: Chiba University
• Principal Investigator: Yabe Rikio 千葉大学, 真菌医学研究センター, 助教 (00598229)
• Research Collaborator: SAIJO Shinobu ; IWAKURA Yoichiro ; CHUNG Soo-Hyun
• Project Period (FY): 2016-04-01 – 2018-03-31
• Keywords: 真菌 / 自然免疫受容体 / サイトカイン

Outline of Final Research Achievements

C-type lectin receptors are a large family of transmembrane proteins containing extracellular C-type lectin-like carbohydrate-recognition domain(s) and signal transduction region(s), i.e., immunoreceptor tyrosine-based activation motif (ITAM) and immunoreceptor tyrosine-based inhibitory motif (ITIM). Although ITAM-coupling CLRs are best-characterized as direct receptors for fungi, the role of ITIM-bearing CLRs has been poorly understood. In this study, we found that a soluble form of inhibitory-type CLRs bound to Candida species. Furthermore, inhibitory-type CLRs mediated inflammatory cytokine production in macrophages and neutrophils following stimulation with those fungi. These data suggest that inhibitory-type CLRs play an important role in immune responses to fungal infection.

Free Research Field

糖鎖生物学