2017 Fiscal Year Final Research Report
Epigenetic regulatory mechanisms of immunoglobulin gene rearrangements in autoimmune diseases
| Project/Area Number |
16K19152
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Immunology
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| Research Institution | Kyoto University |
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Principal Investigator |
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Keywords | 自己免疫疾患 / 免疫グロブリン遺伝子再構成 / SLE |
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| Outline of Final Research Achievements |
Systemic lupus erythematosus (SLE) is a chronic autoimmune inflammatory disease that can affect almost any part of the body, and B cell play critical roles in pathogenesis of SLE through autoantibody production. In a mouse model of SLE, aberrant gene rearrangement and transcription were found at immunoglobulin heavy chain locus in immature B cells. In addition, we observed abnormal bone marrow B-cell development in mouse model of SLE. Moreover, we successfully generated a mouse model for B cell conditional deletion of differentiation regulatory factor.
These findings open the possibility of using immunoglobulin rearrangement status as diagnostic tool for SLE.
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| Free Research Field |
エピジェネティクス
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