2017 Fiscal Year Final Research Report
Regulation of arterosclerisis through induction of endothelial antigen specific regulatory T cell and regulatory B cell
| Project/Area Number |
16K19156
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Immunology
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| Research Institution | Kobe University |
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Principal Investigator |
KASAGI SHIMPEI 神戸大学, 医学部附属病院, 特定助教 (80457051)
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Keywords | 制御性T細胞 / 動脈硬化 / 抗原特異的免疫抑制療法 |
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| Outline of Final Research Achievements |
In the HSP65 (endothelial antigen) derived arterosclerosis model mice, we found that combination therapies of HSP65 antigen and B cell depletion suppressed antigen specific lymphocyte proliferation and cytokine production such as MCP-1, IL-6, TNF-alpha, IL-10. Eventually, development of arterosclerosis was strongly suppressed by these combination therapies.HSP65 specific regulatory T cells and regulatory B cells were induced after combination therapies, which was triggered by TGF-beta produced by macrophages. B cell depletion alone or HSP65 antigen alone did not suppress arteriosclerosis.
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| Free Research Field |
免疫学
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