2017 Fiscal Year Final Research Report
Mechanism of induction of high-functional HIV-1-specific CD8 T cells from naive T cells
| Project/Area Number |
16K19159
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Immunology
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| Research Institution | Kumamoto University |
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Principal Investigator |
KUSE NOZOMI 熊本大学, エイズ学研究センター, 特任助教 (80710409)
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| Research Collaborator |
MURAKOSHI Hayato
AKAHOSHI Tomohiro
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Keywords | HIV-1 / CTL / CD8陽性T細胞 / ナイーブT細胞 / プライミング / STINGリガンド |
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| Outline of Final Research Achievements |
HIV-1-specific CD8+ T cells are required for immune suppression of HIV-1 replication and elimination of the viral reservoirs. However, effective priming method of functional HIV-1-specific CD8+ T cells from naïve T cells remains unclear. The present study demonstrated that STING ligand cGAMP effectively induced functional HIV-specific CD8+ T cells with ability to suppress HIV-1 from naive T cells. These finding suggest that STING ligand is useful for AIDS vaccines and cure treatment.
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| Free Research Field |
感染免疫学
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