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2018 Fiscal Year Final Research Report

Construction and verification of the search method of new side effect expression factor using large scale side effect database

Research Project

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Project/Area Number 16K19175
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Medical sociology
Research InstitutionGifu Pharmaceutical University

Principal Investigator

Noguchi Yoshihiro  岐阜薬科大学, 薬学部, 助教 (80724608)

Project Period (FY) 2016-04-01 – 2019-03-31
Keywordsシグナル検出 / アソシエーション分析 / 併発疾患 / 医薬品相互作用
Outline of Final Research Achievements

This study aimed to construct a simple method to search for side effect agents using side effect spontaneous report database. Since the first problem with the conventional evaluation method is “the number of combinations to be investigated is huge”, we focus on the association analysis, which is one of the analysis methods for big data, in consideration of shortening the analysis time. By the Apriori algorithm used in this analysis method, it was possible to simplify the calculation for calculating the signal value.
Additionally, this analysis method showed the same power as the conventional evaluation method for the signal considering the primary disease and the signal of drug-drug interaction.

Free Research Field

薬剤疫学

Academic Significance and Societal Importance of the Research Achievements

本解析法で用いたAprioriアルゴリズムにより、シグナル値の算出のための演算の簡略化を実施し、原疾患を考慮したケースや医薬品相互作用のシグナルの検出が簡便化された。この成果により、未知の有害事象シグナルを効率よく検出できるようになったと考える。

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Published: 2020-03-30  

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